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Proceedings Paper

Using cellular network diagrams to interpret large-scale datasets: past progress and future challenges
Author(s): Peter D. Karp; Mario Latendresse; Suzanne Paley
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Paper Abstract

Cellular networks are graphs of molecular interactions within the cell. Thanks to the confluence of genome sequencing and bioinformatics, scientists are now able to reconstruct cellular network models for more than 1,000 organisms. A variety of bioinformatics tools have been developed to support the visualization and navigation of cellular network data. Another important application is the use of cellular network diagrams to visualize and interpret large-scale datasets, such as gene-expression data. We present the Cellular Overview, a network visualization tool developed at SRI International (SRI) to support visualization, navigation, and interpretation of large-scale datasets on metabolic networks. Different variations of the diagram have been generated algorithmically for more than 1,000 organisms. We discuss the graphical design of the diagram and its interactive capabilities.

Paper Details

Date Published: 2 February 2011
PDF: 9 pages
Proc. SPIE 7865, Human Vision and Electronic Imaging XVI, 78650G (2 February 2011); doi: 10.1117/12.881997
Show Author Affiliations
Peter D. Karp, SRI International (United States)
Mario Latendresse, SRI International (United States)
Suzanne Paley, SRI International (United States)

Published in SPIE Proceedings Vol. 7865:
Human Vision and Electronic Imaging XVI
Bernice E. Rogowitz; Thrasyvoulos N. Pappas, Editor(s)

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