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Proceedings Paper

Revealing some virus infections by lymphocyte laser scattering
Author(s): Gennady I. Ruban; Vladimir V. Berdnik; Dmitry V. Marinitch; Natalia V. Goncharova; Valery A. Loiko
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Paper Abstract

Light scattering patterns have been calculated for a simple optical model constructed for single smooth and nonsmooth lymphocytes of healthy and infected individuals. It has been shown that the smooth and nonsmooth cells can be resolved using the intensities of the sideward and backward scattered light. We have found by calculations and validated by the flow-cytometer experiments that intensity distributions for the cells of lymphocyte populations can be used as a preliminary signatures of some virus infections. Potential biomedical applications of the findings for label-free flowcytometry detecting of individuals infected with viruses of hepatitises B or C and some others viruses are presented.

Paper Details

Date Published: 7 February 2011
PDF: 8 pages
Proc. SPIE 7994, LAT 2010: International Conference on Lasers, Applications, and Technologies, 79940K (7 February 2011); doi: 10.1117/12.881925
Show Author Affiliations
Gennady I. Ruban, B.I. Stepanov Institute of Physics (Belarus)
Vladimir V. Berdnik, B.I. Stepanov Institute of Physics (Belarus)
Dmitry V. Marinitch, Ctr. of Hematology and Transfusiology (Belarus)
Natalia V. Goncharova, Ctr. of Hematology and Transfusiology (Belarus)
Valery A. Loiko, B.I. Stepanov Institute of Physics (Belarus)


Published in SPIE Proceedings Vol. 7994:
LAT 2010: International Conference on Lasers, Applications, and Technologies
Vladislav Panchenko; Gérard Mourou; Aleksei M. Zheltikov, Editor(s)

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