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Proceedings Paper

Novel design of multimodal MRI/NIR optical contrast agent
Author(s): Kevin Guo; Franck Lin; Walter Akers; Jie Zheng; Bao Teng; Olga Vasalatiy; Gary L. Griffiths; Amir Gandjbakhche; Mikhail Y. Berezin; Samuel Achilefu
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Paper Abstract

We present a novel, dual modality gadolinium based MRI/near-infrared optical probe. Utilizing a fluorescent dye as a scaffold with attached Gd-chelating moiety, we demonstrated a substantial shortening of T1 relaxation time of water protons in vitro. The probe was compared to the commonly used MRI Gd-based contrast agents Magnevist® and Multihance® and showed superior contrast properties. The enhancement was due to strong albumin binding of the hydrophobic fluorophore and overall rigidification of the contrast agent. Due to the near-infrared optical properties of the probe and excellent MRI activity the proposed construct can be potentially utilized as a dual probe in multimodal MRI/NIR optical imaging.

Paper Details

Date Published: 11 February 2011
PDF: 7 pages
Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791015 (11 February 2011); doi: 10.1117/12.881395
Show Author Affiliations
Kevin Guo, Washington Univ. in St. Louis (United States)
Franck Lin, Washington Univ. in St. Louis (United States)
Walter Akers, Washington Univ. in St. Louis (United States)
Jie Zheng, Washington Univ. in St. Louis (United States)
Bao Teng, National Institutes of Health (United States)
Olga Vasalatiy, National Institutes of Health (United States)
Gary L. Griffiths, National Institutes of Health (United States)
Amir Gandjbakhche, National Institutes of Health (United States)
Mikhail Y. Berezin, Washington Univ. in St. Louis (United States)
Samuel Achilefu, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7910:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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