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Proceedings Paper

Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz
Author(s): Christopher Blase; Amit Shelke; Tribikram Kundu; Jürgen Bereiter-Hahn
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Paper Abstract

The mechanical properties of blood vessel walls are important determinants of physiology and pathology of the cardiovascular system. Acoustic imaging (B mode) is routinely used in a clinical setting to determine blood flow and wall distensibility. In this study scanning acoustic microscopy in vitro is used to determine spatially resolved tissue elastic properties. Broadband excitation of 30 MHz has been applied through scanning acoustic microscopy (SAM) for topographical imaging of swine thoracic aorta in reflection mode. Three differently treated tissue samples were investigated with SAM: a) treated with elastase to remove elastin, b) autoclaving for 5 hours to remove collagen and c) fresh controlled untreated sample as control. Experimental investigations are conducted for studying the contribution of individual protein components (elastin and collagen) to the material characteristics of the aortic wall. Conventional tensile testing has been conducted on the tissue samples to study the mechanical behavior. The mechanical properties measured by SAM and tensile testing show qualitative agreement.

Paper Details

Date Published: 1 April 2011
PDF: 11 pages
Proc. SPIE 7984, Health Monitoring of Structural and Biological Systems 2011, 79840Y (1 April 2011); doi: 10.1117/12.881330
Show Author Affiliations
Christopher Blase, Johann Wolfgang Goethe-Univ. (Germany)
Amit Shelke, The Univ. of Arizona (United States)
Tribikram Kundu, The Univ. of Arizona (United States)
Jürgen Bereiter-Hahn, Johann Wolfgang Goethe-Univ. (Germany)


Published in SPIE Proceedings Vol. 7984:
Health Monitoring of Structural and Biological Systems 2011
Tribikram Kundu, Editor(s)

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