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Proceedings Paper

Susceptibility of representative dental pathogens to inactivation by the PDT with water-soluble photosensitizers
Author(s): Ivan Angelov; Vanya Mantareva; Veselin Kussovski; Diter Worle; Hristo Kisov; Marieta Belcheva; Tzvetelina Georgieva; Slavcho Dimitrov
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Paper Abstract

In the recent decade the applications of photodynamic therapy (PDT) rapidly increase in several topics and one of areas where the PDT in the future will be play significant role is dentistry. The different photosensitizing complexes with a good water solubility and with absorption with an intensive maximum in the red region (630-690 nm), which makes them suitable for photodynamic treatments, were investigated. The photochemical properties of complexes for singlet oxygen generation were investigated and were shown relations between uptake levels and light intensity to achieve increase in photodynamic efficacy. Photodynamic efficacy against fungi Candida albicans and bacteria's E. faecalis, MRSA and S. Mutans in planktonic media was evaluated. The high photodynamic efficacy was shown for SiPc at very low concentrations (0.9 μM) and light doses of 50 J cm-2 by intensity of light 60 mW cm-2. The photodynamic response for E. faecalis, MRSA and S. Mutans, after treatments with different photosensitizers show strong dependence on concentrations of photsensitzers and micro organisms. The level of inactivation of the pathogen bacteria's from 1-2 degree of initial concentration up to full inactivation was observed. The studied complexes were compared to the recently studied Methylene blue, Haematoporphyrine and tetra-methylpirydiloxy Zn(II)- phthalocyanines and experimental results show that some of them have a good potential for inactivation of representative pathogenic bacterial strains. Experimental results also indicate that photodynamic therapy appears an effective method for inactivation of oral pathogenic bacterias and fungi.

Paper Details

Date Published: 7 February 2011
PDF: 11 pages
Proc. SPIE 7994, LAT 2010: International Conference on Lasers, Applications, and Technologies, 79941A (7 February 2011); doi: 10.1117/12.881011
Show Author Affiliations
Ivan Angelov, Institute of Organic Chemistry (Bulgaria)
Vanya Mantareva, Institute of Organic Chemistry (Bulgaria)
Veselin Kussovski, The Stephan Angeloff Institute of Microbiology (Bulgaria)
Diter Worle, Univ. of Bremen (Germany)
Hristo Kisov, Medical Univ. of Plovdiv (Bulgaria)
Marieta Belcheva, Medical Univ. of Sofia (Bulgaria)
Tzvetelina Georgieva, Medical Univ. of Sofia (Bulgaria)
Slavcho Dimitrov, Medical Univ. of Sofia (Bulgaria)

Published in SPIE Proceedings Vol. 7994:
LAT 2010: International Conference on Lasers, Applications, and Technologies
Vladislav Panchenko; Gérard Mourou; Aleksei M. Zheltikov, Editor(s)

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