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Proceedings Paper

MPI cell tracking: what can we learn from MRI?
Author(s): Jeff W. M. Bulte; Piotr Walczak; Bernhard Gleich; Jürgen Weizenecker; Denis E. Markov; Hans C. J. Aerts; Hans Boeve; Jörn Borgert; Michael Kuhn
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Paper Abstract

Magnetic resonance imaging (MRI) cell tracking has become an important non-invasive technique to interrogate the fate of cells upon transplantation. At least 6 clinical trials have been published at the end of 2010, all of which have shown that real-time monitoring of the injection procedure, initial engraftment, and short-term biodistribution of cells is critical to further advance the field of cellular therapeutics. In MRI cell tracking, cells are loaded with superparamagnetic iron oxide (SPIO) particles that provide an MRI contrast effect through microscopic magnetic field disturbances and dephasing of protons. Magnetic particle imaging (MPI) has recently emerged as a potential cellular imaging technique that promises to have several advantages over MRI, primarily linear quantification of cells, a higher sensitivity, and "hot spot" tracer identification without confounding background signal. Although probably not fully optimized, SPIO particles that are currently used as MRI contrast agent can be employed as MPI tracer. Initial studies have shown that cells loaded with SPIO particles can give a detectable MPI signal, encouraging further development of MPI cell tracking.

Paper Details

Date Published: 9 March 2011
PDF: 4 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650Z (9 March 2011); doi: 10.1117/12.879844
Show Author Affiliations
Jeff W. M. Bulte, Russell H. Morgan Dept. of Radiology and Radiological Science (United States)
The Johns Hopkins Univ. (United States)
Piotr Walczak, Russell H. Morgan Dept. of Radiology and Radiological Science (United States)
The Johns Hopkins Univ. (United States)
Bernhard Gleich, Philips Medical Systems (Germany)
Jürgen Weizenecker, Karlsruher Institut für Technologie (Germany)
Denis E. Markov, Philips Research Europe (Germany)
Hans C. J. Aerts, Philips Medical Systems (Germany)
Hans Boeve, Koninklijke Philips Electronics N.V. (Netherlands)
Jörn Borgert, Philips Medical Systems (Germany)
Michael Kuhn, Philips Medical Systems (Germany)


Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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