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Proceedings Paper

Image-guided photoacoustic spectroscopy in diagnosis of osteoarthritis in hands: an initial study
Author(s): Zhen Yuan; J. Xiao; Yao Sun; Eric S. Sobel; Jishan He; Huabei Jiang
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Paper Abstract

We present for the first time in vivo experimental evidence that multispectral quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a multispectral PAT scanner. Images of tissue physiological/functional parameters including oxy-hemoglobin, deoxyhemoglobin, oxygen saturation and water content along with tissue acoustic velocity of all the examined joints were simultaneously recovered using a finite element reconstruction algorithm for multispectral photoacoustic measurements. The recovered multispectral photoacoustic images show that the OA joints have significantly elevated water content, decreased oxygen saturation, and increased acoustic velocity compared to the normal joints.

Paper Details

Date Published: 18 February 2011
PDF: 17 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78834N (18 February 2011); doi: 10.1117/12.879439
Show Author Affiliations
Zhen Yuan, Univ. of Florida (United States)
J. Xiao, Central South Univ. (China)
Yao Sun, Univ. of Florida (United States)
Eric S. Sobel, Univ. of Florida (United States)
Jishan He, Central South Univ. (China)
Huabei Jiang, Univ. of Florida (United States)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Bodo E. Knudsen; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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