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Proceedings Paper

A hybrid positron and OCT intraoperative probe for ovarian cancer detection and characterization
Author(s): Yi Yang; Nrusingh C. Biswal; Tianheng Wang; Patrick Kumavor; Mozafareddin Karimeddini; Melinda Sanders; Molly Brewer; Quing Zhu
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Paper Abstract

Ovarian cancer has the lowest survival rate of the gynecologic cancers with a 5-year survival of about 50% in the United States. With current screening and diagnostic abilities for ovarian cancers, most of the diagnosed patients are already with advanced stages and the majority of them will die of this deadly disease. In this paper, we report a multimodal imaging approach which combines optical coherence tomography (OCT) and positron detection for early ovarian cancer detection. The dual modality system has the capability of providing both functional and morphological images simultaneously. While the positron detection provides the metabolism activity of the ovary due to the uptake of radiotracer, the OCT provides the high resolution (25μm X 25μm X 12μm - longitudinal X lateral X axial in air) structural imaging at 20k A-lines per second. Total 18 ovaries obtained from 10 patients classified as normal, abnormal and malignant ovarian tissues were characterized ex vivo. Positron counts of 1.2-fold higher was found between abnormal and normal ovaries and 3~30-fold higher was found between malignant and normal ovaries. OCT imaging of malignant and abnormal ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in the ovary.

Paper Details

Date Published: 10 February 2011
PDF: 8 pages
Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920Y (10 February 2011); doi: 10.1117/12.878860
Show Author Affiliations
Yi Yang, Univ. of Connecticut (United States)
Nrusingh C. Biswal, Univ. of Connecticut (United States)
Tianheng Wang, Univ. of Connecticut (United States)
Patrick Kumavor, Univ. of Connecticut (United States)
Mozafareddin Karimeddini, Univ. of Connecticut Health Ctr. (United States)
Melinda Sanders, Univ. of Connecticut Health Ctr. (United States)
Molly Brewer, Univ. of Connecticut Health Ctr. (United States)
Quing Zhu, Univ. of Connecticut (United States)

Published in SPIE Proceedings Vol. 7892:
Multimodal Biomedical Imaging VI
Fred S. Azar; Xavier Intes, Editor(s)

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