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Proceedings Paper

Endoscopic device for functional imaging of the retina
Author(s): Simon Barriga; Sweyta Lohani; Bret Martell; Peter Soliz; Dan Ts'o
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Paper Abstract

Non-invasive imaging of retinal function based on the recording of spatially distributed reflectance changes evoked by visual stimuli has to-date been performed primarily using modified commercial fundus cameras. We have constructed a prototype retinal functional imager, using a commercial endoscope (Storz) for the frontend optics, and a low-cost back-end that includes the needed dichroic beam splitter to separate the stimulus path from the imaging path. This device has been tested to demonstrate its performance for the delivery of adequate near infrared (NIR) illumination, intensity of the visual stimulus and reflectance return in the imaging path. The current device was found to be capable of imaging reflectance changes of 0.1%, similar to that observable using the modified commercial fundus camera approach. The visual stimulus (a 505nm spot of 0.5secs) was used with an interrogation illumination of 780nm, and a sequence of imaged captured. At each pixel, the imaged signal was subtracted and normalized by the baseline reflectance, so that the measurement was ΔR/R. The typical retinal activity signal observed had a ΔR/R of 0.3-1.0%. The noise levels were measured when no stimulus was applied and found to vary between ± 0.05%. Functional imaging has been suggested as a means to provide objective information on retina function that may be a preclinical indicator of ocular diseases, such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy. The endoscopic approach promises to yield a significantly more economical retinal functional imaging device that would be clinically important.

Paper Details

Date Published: 11 February 2011
PDF: 8 pages
Proc. SPIE 7885, Ophthalmic Technologies XXI, 78851S (11 February 2011); doi: 10.1117/12.878797
Show Author Affiliations
Simon Barriga, VisionQuest Biomedical, LLC (United States)
Univ. of New Mexico (United States)
Sweyta Lohani, SUNY Upstate Medical Univ. (United States)
Bret Martell, SUNY Upstate Medical Univ. (United States)
Peter Soliz, VisionQuest Biomedical, LLC (United States)
Univ. of Iowa (United States)
Dan Ts'o, SUNY Upstate Medical Univ. (United States)

Published in SPIE Proceedings Vol. 7885:
Ophthalmic Technologies XXI
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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