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Proceedings Paper

Chemical binding affinity estimation using MSB
Author(s): John B. Weaver; Adam M. Rauwerdink
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Paper Abstract

Binding affinity can be estimated in several ways in the laboratory but there is no viable way to estimate binding affinity in vivo without assumptions on the number of binding sites. Magnetic spectroscopy of nanoparticle Brownian motion, MSB, measures the rotational Brownian motion. The MSB signal is affected by nanoparticle binding affinity so it provides a mechanism to measure the chemical binding affinity. We present a possible mechanism to quantify the binding affinity and test that mechanism using viscous solutions.

Paper Details

Date Published: 16 March 2011
PDF: 7 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650Y (16 March 2011); doi: 10.1117/12.878788
Show Author Affiliations
John B. Weaver, Dartmouth-Hitchcock Medical Ctr. (United States)
Thayer School of Engineering, Dartmouth College (United States)
Norris Cotton Cancer Ctr., Dartmouth Medical School (United States)
Adam M. Rauwerdink, Thayer School of Engineering, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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