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Proceedings Paper

Assessing topographic cutaneous autofluorescence variation using fluorescence UV and visible excitation emission matrix (EEM) spectroscopy
Author(s): Jianhua Zhao; Soodabeh Zandi; Florina Feng; Haishan Zeng; David I. McLean; Harvey Lui
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Paper Abstract

Cutaneous autofluorescence properties were systematically studied using fluorescence excitation emission matrix spectroscopy. Twenty-six healthy subjects with a mean age of 34 (range 21-74) participated in this study. The fluorescence of major skin fluorophores such as tryptophan, collagen, elastin and NADH could be readily identified. On average, facial skin shows strong tryptophan and measurable porphyrin fluorescence; the palm and nail show strong tryptophan and keratin fluorescence. These results demonstrate that regional topographic variations exist not only in the amount of fluorescence but also in the relative distribution of fluorophores in normal skin. Moreover this provides a basis for future interpretation of autofluorescence in diseased skin.

Paper Details

Date Published: 18 February 2011
PDF: 5 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78830I (18 February 2011); doi: 10.1117/12.878770
Show Author Affiliations
Jianhua Zhao, The Univ. of British Columbia (Canada)
The BC Cancer Agency Research Ctr. (Canada)
Soodabeh Zandi, The Univ. of British Columbia (Canada)
Kerman Univ. of Medical Sciences (Iran, Islamic Republic of)
Florina Feng, The Univ. of British Columbia (Canada)
Haishan Zeng, The Univ. of British Columbia (Canada)
The BC Cancer Agency Research Ctr. (Canada)
David I. McLean, The Univ. of British Columbia (Canada)
BC Cancer Agency Research Ctr. (Canada)
Harvey Lui, The Univ. of British Columbia (Canada)
BC Cancer Agency Research Ctr. (Canada)


Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong; Justus F. R. Ilgner; Bodo E. Knudsen; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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