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Proceedings Paper

Experimental demonstration of x-space magnetic particle imaging
Author(s): Patrick W. Goodwill; Steven M. Conolly
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Paper Abstract

We have developed a new systems theory for analyzing Magnetic Particle Imaging (MPI), x-space MPI, that motivates an image reconstruction technique requiring only a simple scaling and mapping of the raw signal to image space. As a result, reconstruction time scales linearly with image size. Moreover, we expect there to be no noise gain due to performing a matrix inverse. Reconstruction is simple and can be performed in real-time. Furthermore, there is no "System Function" and no requirement to pre-characterize the nanoparticle in the imaging system before imaging. So far, there has not been an experimental test of the x-space theory on an imaging system. In this paper we begin by describing the theoretical signal that we would expect from the imager for a SPIO nanoparticle source. We then construct a small scale MPI imager to test x-space. We conclude with images from the x-space scanner using the iron oxide tracer Resovist. Our preliminary images show 1.6 mm spatial resolution using a 6.0 T/m gradient that closely matches the expected image resolution from x-space theory. In conclusion, our data supports the theory that MPI can be considered a linear, shift invariant system. This bodes well for the future as we scale MPI scanners to human sizes as large images can be reconstructed simply and rapidly.

Paper Details

Date Published: 9 March 2011
PDF: 6 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650U (9 March 2011); doi: 10.1117/12.878659
Show Author Affiliations
Patrick W. Goodwill, Univ. of California, Berkeley (United States)
Steven M. Conolly, Univ. of California, Berkeley (United States)

Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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