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Proceedings Paper

Texture-based segmentation and analysis of emphysema depicted on CT images
Author(s): Jun Tan; Bin Zheng; Xingwei Wang; Dror Lederman; Jiantao Pu; Frank C. Sciurba; David Gur; J. Ken Leader
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Paper Abstract

In this study we present a texture-based method of emphysema segmentation depicted on CT examination consisting of two steps. Step 1, a fractal dimension based texture feature extraction is used to initially detect base regions of emphysema. A threshold is applied to the texture result image to obtain initial base regions. Step 2, the base regions are evaluated pixel-by-pixel using a method that considers the variance change incurred by adding a pixel to the base in an effort to refine the boundary of the base regions. Visual inspection revealed a reasonable segmentation of the emphysema regions. There was a strong correlation between lung function (FEV1%, FEV1/FVC, and DLCO%) and fraction of emphysema computed using the texture based method, which were -0.433, -.629, and -0.527, respectively. The texture-based method produced more homogeneous emphysematous regions compared to simple thresholding, especially for large bulla, which can appear as speckled regions in the threshold approach. In the texture-based method, single isolated pixels may be considered as emphysema only if neighboring pixels meet certain criteria, which support the idea that single isolated pixels may not be sufficient evidence that emphysema is present. One of the strength of our complex texture-based approach to emphysema segmentation is that it goes beyond existing approaches that typically extract a single or groups texture features and individually analyze the features. We focus on first identifying potential regions of emphysema and then refining the boundary of the detected regions based on texture patterns.

Paper Details

Date Published: 9 March 2011
PDF: 7 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79651V (9 March 2011); doi: 10.1117/12.878279
Show Author Affiliations
Jun Tan, Univ. of Pittsburgh Medical Ctr. (United States)
Bin Zheng, Univ. of Pittsburgh Medical Ctr. (United States)
Xingwei Wang, Univ. of Pittsburgh Medical Ctr. (United States)
Dror Lederman, Univ. of Pittsburgh Medical Ctr. (United States)
Jiantao Pu, Univ. of Pittsburgh Medical Ctr. (United States)
Frank C. Sciurba, Univ. of Pittsburgh Medical Ctr. (United States)
David Gur, Univ. of Pittsburgh Medical Ctr. (United States)
J. Ken Leader, Univ. of Pittsburgh Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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