Share Email Print

Proceedings Paper

Use of Mueller polarimetric imaging for the staging of human colon cancer
Author(s): Angelo Pierangelo; Sandeep Manhas; Abdelali Benali; Maria Rosaria Antonelli; Tatiana Novikova; Pierre Validire; Brice Gayet; Antonello De Martino
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In this paper we show the results of multi-spectral Mueller Imaging applied to the analysis of human colon cancer in a backscattering configuration with diffuse light illumination. The analyzed sample behaves as a pure depolarizer. The depolarization power, for both healthy and cancerous zones, is lower for linearly than for circularly polarized incident light for all used wavelengths and increases with increasing wavelength. Based on their visual staging and polarimetric responses, we chose specific zones which we correlated to the histology of the corresponding cuts. The histological examination shows that we see a multilayer interaction in both healthy and abnormal zones, if the light penetration depth is sufficient. The measured depolarization depends on several factors: the presence or absence of tumor, the microscopic structure of cancer (ratio between cellular density and stroma), its exophytic (budding) or endophytic (penetrating) nature, its thickness, the degree of cancer penetration in deeper layers and the nature of healthy tissue left under abnormal layers. These results demonstrate that multi-spectral Mueller imaging can provide useful contrasts for the quick staging of human colon cancer ex-vivo, with additional information about cancerous zones with different microscopic structures.

Paper Details

Date Published: 1 March 2011
PDF: 8 pages
Proc. SPIE 7895, Optical Biopsy IX, 78950E (1 March 2011); doi: 10.1117/12.878248
Show Author Affiliations
Angelo Pierangelo, LPICM, Ecole Polytechnique, CNRS (France)
Sandeep Manhas, LPICM, Ecole Polytechnique, CNRS (France)
Abdelali Benali, Institut Mutualiste Montsouris (France)
Maria Rosaria Antonelli, LPICM, Ecole Polytechnique, CNRS (France)
Tatiana Novikova, LPICM, Ecole Polytechnique, CNRS (France)
Pierre Validire, Institut Mutualiste Montsouris (France)
Brice Gayet, Institut Mutualiste Montsouris (France)
Antonello De Martino, LPICM, Ecole Polytechnique, CNRS (France)

Published in SPIE Proceedings Vol. 7895:
Optical Biopsy IX
Robert R. Alfano, Editor(s)

© SPIE. Terms of Use
Back to Top