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Proceedings Paper

Detection and mapping of delays in early cortical folding derived from in utero MRI
Author(s): Piotr A. Habas; Vidya Rajagopalan; Julia A. Scott; Kio Kim; Ahmad Roosta; Francois Rousseau; A. James Barkovich; Orit A. Glenn; Colin Studholme
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Paper Abstract

Understanding human brain development in utero and detecting cortical abnormalities related to specific clinical conditions is an important area of research. In this paper, we describe and evaluate methodology for detection and mapping of delays in early cortical folding from population-based studies of fetal brain anatomies imaged in utero. We use a general linear modeling framework to describe spatiotemporal changes in curvature of the developing brain and explore the ability to detect and localize delays in cortical folding in the presence of uncertainty in estimation of the fetal age. We apply permutation testing to examine which regions of the brain surface provide the most statistical power to detect a given folding delay at a given developmental stage. The presented methodology is evaluated using MR scans of fetuses with normal brain development and gestational ages ranging from 20.57 to 27.86 weeks. This period is critical in early cortical folding and the formation of the primary and secondary sulci. Finally, we demonstrate a clinical application of the framework for detection and localization of folding delays in fetuses with isolated mild ventriculomegaly.

Paper Details

Date Published: 11 March 2011
PDF: 7 pages
Proc. SPIE 7962, Medical Imaging 2011: Image Processing, 79620O (11 March 2011); doi: 10.1117/12.877749
Show Author Affiliations
Piotr A. Habas, Univ. of California, San Francisco (United States)
Vidya Rajagopalan, Univ. of California, San Francisco (United States)
Julia A. Scott, Univ. of California, San Francisco (United States)
Kio Kim, Univ. of California, San Francisco (United States)
Ahmad Roosta, Univ. of California, San Francisco (United States)
Univ. of California, Berkeley (United States)
Francois Rousseau, LSIIT, CNRS, Univ. of Strasbourg (France)
A. James Barkovich, Univ. of California, San Francisco (United States)
Orit A. Glenn, Univ. of California, San Francisco (United States)
Colin Studholme, Univ. of California, San Francisco (United States)


Published in SPIE Proceedings Vol. 7962:
Medical Imaging 2011: Image Processing
Benoit M. Dawant; David R. Haynor, Editor(s)

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