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Proceedings Paper

Automated segmentation of ventricles from serial brain MRI for the quantification of volumetric changes associated with communicating hydrocephalus in patients with brain tumor
Author(s): John A. Pura; Allison M. Hamilton; Geoffrey A. Vargish; John A. Butman; Marius George Linguraru
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Paper Abstract

Accurate ventricle volume estimates could improve the understanding and diagnosis of postoperative communicating hydrocephalus. For this category of patients, associated changes in ventricle volume can be difficult to identify, particularly over short time intervals. We present an automated segmentation algorithm that evaluates ventricle size from serial brain MRI examination. The technique combines serial T1- weighted images to increase SNR and segments the means image to generate a ventricle template. After pre-processing, the segmentation is initiated by a fuzzy c-means clustering algorithm to find the seeds used in a combination of fast marching methods and geodesic active contours. Finally, the ventricle template is propagated onto the serial data via non-linear registration. Serial volume estimates were obtained in an automated robust and accurate manner from difficult data.

Paper Details

Date Published: 9 March 2011
PDF: 8 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650P (9 March 2011); doi: 10.1117/12.877679
Show Author Affiliations
John A. Pura, National Institutes of Health (United States)
Allison M. Hamilton, National Institutes of Health (United States)
Geoffrey A. Vargish, National Institutes of Health (United States)
John A. Butman, National Institutes of Health (United States)
Marius George Linguraru, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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