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Proceedings Paper

Micro-CT characterization of human trabecular bone in osteogenesis imperfecta
Author(s): John Jameson; Carolyne Albert; Peter Smith; Robert Molthen; Gerald Harris
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Paper Abstract

Osteogenesis imperfecta (OI) is a genetic syndrome affecting collagen synthesis and assembly. Its symptoms vary widely but commonly include bone fragility, reduced stature, and bone deformity. Because of the small size and paucity of human specimens, there is a lack of biomechanical data for OI bone. Most literature has focused on histomorphometric analyses, which rely on assumptions to extrapolate 3-D properties. In this study, a micro-computed tomography (μCT) system was used to directly measure structural and mineral properties in pediatric OI bone collected during routine surgical procedures. Surface renderings suggested a poorly organized, plate-like orientation. Patients with a history of bone-augmenting drugs exhibited increased bone volume fraction (BV/TV), trabecular number (Tb.N), and connectivity density (Eu.Conn.D). The latter two parameters appeared to be related to OI severity. Structural results were consistently higher than those reported in a previous histomorphometric study, but these differences can be attributed to factors such as specimen collection site, drug therapy, and assumptions associated with histomorphometry. Mineral testing revealed strong correlations with several structural parameters, highlighting the importance of a dual approach in trabecular bone testing. This study reports some of the first quantitative μCT data of human OI bone, and it suggests compelling possibilities for the future of OI bone assessment.

Paper Details

Date Published: 9 March 2011
PDF: 8 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650I (9 March 2011); doi: 10.1117/12.877586
Show Author Affiliations
John Jameson, Marquette Univ. (United States)
Orthopaedic & Rehabilitation Engineering Ctr. (United States)
Carolyne Albert, Marquette Univ. (United States)
Orthopaedic & Rehabilitation Engineering Ctr. (United States)
Peter Smith, Orthopaedic & Rehabilitation Engineering Ctr. (United States)
Shriners Hospitals for Children (United States)
Robert Molthen, Marquette Univ. (United States)
Orthopaedic & Rehabilitation Engineering Ctr. (United States)
Medical College of Wisconsin (United States)
Gerald Harris, Marquette Univ. (United States)
Orthopaedic & Rehabilitation Engineering Ctr. (United States)
Shriners Hospitals for Children (United States)


Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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