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Proceedings Paper

Toward comprehensive detection of sight threatening retinal disease using a multiscale AM-FM methodology
Author(s): C. Agurto; S. Barriga; V. Murray; S. Murillo; G. Zamora; W. Bauman; M. Pattichis; P. Soliz
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Paper Abstract

In the United States and most of the western world, the leading causes of vision impairment and blindness are age-related macular degeneration (AMD), diabetic retinopathy (DR), and glaucoma. In the last decade, research in automatic detection of retinal lesions associated with eye diseases has produced several automatic systems for detection and screening of AMD, DR, and glaucoma. However. advanced, sight-threatening stages of DR and AMD can present with lesions not commonly addressed by current approaches to automatic screening. In this paper we present an automatic eye screening system based on multiscale Amplitude Modulation-Frequency Modulation (AM-FM) decompositions that addresses not only the early stages, but also advanced stages of retinal and optic nerve disease. Ten different experiments were performed in which abnormal features such as neovascularization, drusen, exudates, pigmentation abnormalities, geographic atrophy (GA), and glaucoma were classified. The algorithm achieved an accuracy detection range of [0.77 to 0.98] area under the ROC curve for a set of 810 images. When set to a specificity value of 0.60, the sensitivity of the algorithm to the detection of abnormal features ranged between 0.88 and 1.00. Our system demonstrates that, given an appropriate training set, it is possible to use a unique algorithm to detect a broad range of eye diseases.

Paper Details

Date Published: 4 March 2011
PDF: 12 pages
Proc. SPIE 7963, Medical Imaging 2011: Computer-Aided Diagnosis, 796316 (4 March 2011); doi: 10.1117/12.877498
Show Author Affiliations
C. Agurto, VisionQuest Biomedical, LLC (United States)
The Univ. of New Mexico (United States)
S. Barriga, VisionQuest Biomedical, LLC (United States)
V. Murray, VisionQuest Biomedical, LLC (United States)
The Univ. of New Mexico (United States)
S. Murillo, VisionQuest Biomedical, LLC (United States)
G. Zamora, VisionQuest Biomedical, LLC (United States)
W. Bauman, Retina Institute of South Texas (United States)
M. Pattichis, The Univ. of New Mexico (United States)
P. Soliz, VisionQuest Biomedical, LLC (United States)
The Univ. of Iowa (United States)

Published in SPIE Proceedings Vol. 7963:
Medical Imaging 2011: Computer-Aided Diagnosis
Ronald M. Summers; Bram van Ginneken, Editor(s)

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