Share Email Print
cover

Proceedings Paper

Image-guided prostate sectioning supporting registration of graded cancerous foci from digital histopathology images to in vivo MRI: an interactive 3D visualization tool
Author(s): E. Gibson; A. Fenster; C. Crukley; C. McKenzie; J. A. Gomez; M. Moussa; G. Bauman; A. D. Ward
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Personalized treatment of prostate cancer would be enhanced by an assessment of cancer stage and grade from imaging, the validation of which requires the accurate co-registration of in vivo images with a gold standard for stage and grade established by histopathology. We present a visualization tool supporting an image-guided approach enabling the acquisition of histopathology images parallel to the in vivo imaging planes, simplifying this registration. This tool decreases imaging-to-specimen landmark alignment error by 62%, and decreases the time required to mark the slicing plane on the specimen by 47%. Preliminary results from our method demonstrate the alignment of regions suspicious for cancer on T2w MRI with confirmed cancer foci on histopathology, and we calculate a sub-millimeter in-plane target registration error.

Paper Details

Date Published: 9 March 2011
PDF: 6 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650D (9 March 2011); doi: 10.1117/12.877468
Show Author Affiliations
E. Gibson, Robarts Research Institute (Canada)
A. Fenster, Robarts Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Lawson Health Research Institute (Canada)
C. Crukley, Robarts Research Institute (Canada)
C. McKenzie, The Univ. of Western Ontario (Canada)
Lawson Health Research Institute (Canada)
J. A. Gomez, The Univ. of Western Ontario (Canada)
M. Moussa, The Univ. of Western Ontario (Canada)
G. Bauman, The Univ. of Western Ontario (Canada)
A. D. Ward, Robarts Research Institute (Canada)
The Univ. of Western Ontario (Canada)


Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

© SPIE. Terms of Use
Back to Top