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Proceedings Paper

White matter alterations in temporal lobe epilepsy
Author(s): P. B. Diniz; C. E. Salmon; T. R. Velasco; A. C. Sakamoto; J. P. Leite; A. C. Santos
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Paper Abstract

In This study, we used Fractional anisotropy (FA), mean diffusivity (D), parallel diffusivity (D//) and perpendicular diffusivity (D), to localize the regions where occur axonal lesion and demyelization. TBSS was applied to analyze the FA data. After, the regions with alteration were studied with D, D// and D maps. Patients exhibited widespread degradation of FA. With D, D// and D maps analysis we found alterations in corpus callosum, corticospinal tract, fornix, internal capsule, corona radiate, Sagittal stratum, cingulum, fronto-occipital fasciculus and uncinate fasciculus. Our results are consistent with the hypothesis that exist demyelization and axonal damage in patients with TLE.

Paper Details

Date Published: 16 March 2011
PDF: 7 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 796527 (16 March 2011); doi: 10.1117/12.877190
Show Author Affiliations
P. B. Diniz, Univ. de São Paulo (Brazil)
C. E. Salmon, Univ. de São Paulo (Brazil)
T. R. Velasco, Univ. de São Paulo (Brazil)
A. C. Sakamoto, Univ. de São Paulo (Brazil)
J. P. Leite, Univ. de São Paulo (Brazil)
A. C. Santos, Univ. de São Paulo (Brazil)


Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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