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Proceedings Paper

Gold nanorods for applications in biological imaging
Author(s): Y. Zhang; J. Yu; D. J. S. Birch; Y. Chen
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Paper Abstract

Two-Photon luminescence (TPL) from gold nanorods shows considerable potential in biological imaging for high resolution, low photo-damage, tunable near infra-red (NIR) longitudinal band, polarization dependence, ability to conjugate to bio-molecules and low toxicity. Here we demonstrate the application of gold nanorods as TPL imaging agents by studying the gold nanorods taken up by Madin-Darby canine kidney (MDCK) cells using both confocal imaging and fluorescence lifetime imaging microscopy (FLIM). The characteristic luminescence lifetime of gold nanorods is found to be less than 100 ps, which can be used to distinguish gold nanorods from other fluorescent labels and endogenous fluorophores in lifetime imaging.

Paper Details

Date Published: 12 February 2011
PDF: 6 pages
Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101H (12 February 2011); doi: 10.1117/12.877156
Show Author Affiliations
Y. Zhang, Univ. of Strathclyde (United Kingdom)
J. Yu, Univ. of Strathclyde (United Kingdom)
D. J. S. Birch, Univ. of Strathclyde (United Kingdom)
Y. Chen, Univ. of Strathclyde (United Kingdom)


Published in SPIE Proceedings Vol. 7910:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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