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Proceedings Paper

Studying depletion kinetics of circulating prostate cancer cells by in vivo flow cytometer
Author(s): Guangda Liu; Zhengqin Gu; Jin Guo; Yan Li; Yun Chen; Tong Chen; Cheng Wang; Xunbin Wei
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Paper Abstract

Prostate cancer is the most common malignancy in American men and the second leading cause of deaths from cancer, after lung cancer. The tumor usually grows slowly and remains confined to the gland for many years. During this time, the tumor produces little or no symptoms or outward signs. As the cancer advances, however, it can metastasize throughout other areas of the body, such as the bones, lungs, and liver. Surgical resection, hormonal therapy, chemotherapy and radiation therapy are the foundation of current prostate cancer therapies. Treatments for prostate cause both short- and long-term side effects that may be difficult to accept. Molecular mechanisms of prostate cancer metastasis need to be understood better and new therapies must be developed to selectively target to unique characteristics of cancer cell growth and metastasis. We have developed the "in vivo microscopy" to study the mechanisms that govern prostate cancer cell spread through the microenvironment in vivo in real-time confocal near-infrared fluorescence imaging. A recently developed "in vivo flow cytometer" and optical imaging are used to assess prostate cancer cell spreading and the circulation kinetics of prostate cancer cells. A real- time quantitative monitoring of circulating prostate cancer cells by the in vivo flow cytometer will be useful to assess the effectiveness of the potential therapeutic interventions.

Paper Details

Date Published: 10 February 2011
PDF: 8 pages
Proc. SPIE 7900, Biophotonics and Immune Responses VI, 79000C (10 February 2011); doi: 10.1117/12.877100
Show Author Affiliations
Guangda Liu, Fudan Univ. (China)
Zhengqin Gu, Xinhua Hospital, Shanghai Jiaotong Univ. (China)
Jin Guo, Fudan Univ. (China)
Yan Li, Fudan Univ. (China)
Yun Chen, Fudan Univ. (China)
Tong Chen, Huashan Hospital, Fudan Univ. (China)
Cheng Wang, Univ. of Shanghai for Science and Technology (China)
Xunbin Wei, Fudan Univ. (China)


Published in SPIE Proceedings Vol. 7900:
Biophotonics and Immune Responses VI
Wei R. Chen, Editor(s)

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