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Proceedings Paper

The impact of motion correction on lesion characterization in DCE breast MR images
Author(s): Martin Bergtholdt; Sven Kabus; Rafael Wiemker; Thomas Buelow
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Paper Abstract

In the context of dynamic contrast enhanced breast MR imaging we analyzed the effect of motion compensating registration on the characterization of lesions. Two registration techniques were applied: 1) rigid registration and 2) elastic registration based on the Navier-Lam´e equation. Interpreting voxels that exhibit a decline in image intensity after contrast injection (compared to the non-contrasted native image) as motion outliers, it can be shown that the rate of motion outliers can be largely reduced by both rigid and elastic registration. The performance of lesion features, including maximal signal enhancement ratio and variance of the signal enhancement ratio, was measured by area under the ROC curve as well as Cohen's κ and showed significant improvement for elastic registration, whereas features derived from rigidly registered images did not in general exhibit a significant improvement over the level of unregistered data.

Paper Details

Date Published: 4 March 2011
PDF: 9 pages
Proc. SPIE 7963, Medical Imaging 2011: Computer-Aided Diagnosis, 79630Z (4 March 2011); doi: 10.1117/12.877090
Show Author Affiliations
Martin Bergtholdt, Philips Research (Germany)
Sven Kabus, Philips Research (Germany)
Rafael Wiemker, Philips Research (Germany)
Thomas Buelow, Philips Research (Germany)


Published in SPIE Proceedings Vol. 7963:
Medical Imaging 2011: Computer-Aided Diagnosis
Ronald M. Summers M.D.; Bram van Ginneken, Editor(s)

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