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Proceedings Paper

fMRI analysis software tools: an evaluation framework
Author(s): Valentina Pedoia; Vittoria Colli; Sabina Strocchi; Cristina Vite; Elisabetta Binaghi; Leopoldo Conte
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Paper Abstract

Performance comparison of functional Magnetic Resonance Imaging (fMRI) software tools is a very difficult task. In this paper, a framework for comparison of fMRI analysis results obtained with different software packages is proposed. An objective evaluation is possible only after pre-processing steps that normalize input data in a standard domain. Segmentation and registration algorithms are implemented in order to classify voxels belonging to brain or not, and to find the non rigid transformation that best aligns the volume under inspection with a standard one. Through the definitions of intersection and union of fuzzy logic an index was defined which quantify information overlap between Statistical Parametrical Maps (SPMs). Direct comparison between fMRI results can only highlight differences. In order to assess the best result, an index that represents the goodness of the activation detection is required. The transformation of the activation map in a standard domain allows the use of a functional Atlas for labeling the active voxels. For each functional area the Activation Weighted Index (AWI) that identifies the mean activation level of whole area was defined. By means of this brief, but comprehensive description, it is easy to find a metric for the objective evaluation of a fMRI analysis tools. Trough the first evaluation method the situations where the SPMs are inconsistent were identified. The result of AWI analysis suggest which tool has higher sensitivity and specificity. The proposed method seems a valid evaluation tool when applied to an adequate number of patients.

Paper Details

Date Published: 15 March 2011
PDF: 9 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 796528 (15 March 2011); doi: 10.1117/12.877067
Show Author Affiliations
Valentina Pedoia, Univ. degli Studi dell'Insubria (Italy)
Vittoria Colli, Ospedale di Circolo e Fondazione Macchi Varese (Italy)
Sabina Strocchi, Ospedale di Circolo e Fondazione Macchi Varese (Italy)
Cristina Vite, Ospedale di Circolo e Fondazione Macchi Varese (Italy)
Elisabetta Binaghi, Univ. degli Studi dell'Insubria (Italy)
Leopoldo Conte, Univ. degli Studi dell'Insubria (Italy)

Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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