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Proceedings Paper

Dye-biomolecule conjugates and NIR-fluorescent particles for targeting of disease-related biomarkers
Author(s): J. Pauli; R. Brehm; M. Grabolle; T. Behnke; J. Mathejczyk; F. Hamann; F. Alves; I. Hilger; U. Resch-Genger
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Paper Abstract

Indispensable for fluorescence imaging are highly specific and sensitive molecular probes that absorb and emit in the near infrared (NIR) spectral region and respond to or target molecular species or processes. Here, we present approaches to targeted fluorescent probes for in vivo imaging in the intensity and lifetime domain exploiting NIR dyes. Screening schemes for the fast identification of suitable fluorophores are derived and design criteria for highly emissive optical probes. In addition, as a signal amplification strategy that enables also the use of hydrophobic NIR fluorophores as fluorescent reporters, first steps towards versatile strategies for the preparation of NIR-fluorescent polymeric particles are presented that can be utilized also for the design of targeted and analyte-responsive probes.

Paper Details

Date Published: 11 February 2011
PDF: 15 pages
Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791014 (11 February 2011); doi: 10.1117/12.876828
Show Author Affiliations
J. Pauli, Bundesanstalt für Materialforschung und -prüfung (Germany)
R. Brehm, Bundesanstalt für Materialforschung und -prüfung (Germany)
M. Grabolle, Bundesanstalt für Materialforschung und -prüfung (Germany)
T. Behnke, Bundesanstalt für Materialforschung und -prüfung (Germany)
J. Mathejczyk, Max-Planck-Institut für experimentelle Medizin (Germany)
F. Hamann, Univ. Hospital Jena (Germany)
F. Alves, Max-Planck-Institut für experimentelle Medizin (Germany)
I. Hilger, Univ. Hospital Jena (Germany)
U. Resch-Genger, Bundesanstalt für Materialforschung und -prüfung (Germany)


Published in SPIE Proceedings Vol. 7910:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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