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Proceedings Paper

In vivo longitudinal photoacoustic imaging of subcutaneous tumours in mice
Author(s): Jan Laufer; Peter Johnson; Edward Zhang; Bradley Treeby; Ben Cox; Barbara Pedley; Paul Beard
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Paper Abstract

Photoacoustic tomography can provide high resolution 3D images of vascular networks, making it well suited to characterising the development of tumour vasculature and its response to treatment. In this study, photoacoustic images to depths of up to 9 mm were obtained using an all optical ultrasound detection scheme. Two type of colorectal tumours (LS174T and SW1222) implanted subcutaneously in a mouse were studied. 3D photoacoustic images were obtained in vivo revealing the different vascular architectures of each tumour type and their evolution over a period of several days. The results suggest that photoacoustic imaging could play a role in providing essential pre-clinical information on tumour pathophysiology and eliciting the biological mechanisms underlying anti-angiogenic therapies and other treatments.

Paper Details

Date Published: 28 February 2011
PDF: 6 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789915 (28 February 2011); doi: 10.1117/12.876782
Show Author Affiliations
Jan Laufer, Univ. College London (United Kingdom)
Peter Johnson, Univ. College London (United Kingdom)
Edward Zhang, Univ. College London (United Kingdom)
Bradley Treeby, Univ. College London (United Kingdom)
Ben Cox, Univ. College London (United Kingdom)
Barbara Pedley, Univ. College London (United Kingdom)
Paul Beard, Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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