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Proceedings Paper

Motion correction in spatial frequency domain imaging; optical property determination in pigmented lesions
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Paper Abstract

Background and Objective: Spatial Frequency Domain Imaging (SFDI) is a non-contact wide-field optical imaging technology currently being used to study the optical properties and chromophore concentrations of in-vivo malignant melanomas and benign pigmented lesions. Our objective is to develop a motion correction procedure in order to assess the concerns of subject-motion related variables during clinical measurements. Study Design/Materials and Methods: SFDI motion-correction is a two-part procedure which utilizes a fiduciary marker and canny-edge detection in order to reposition and align the frame-to-frame regions-of-interest (ROI). Motioninduced phase-shifts are subsequently sampled before the entire image-set is processed by a modified demodulation formula. By comparing the results of the adjusted processing method with data gathered from the current non-corrected method, we were able to systematically characterize the impact of motion variables on SFDI measurements. Results: Motion-corrected SFDI data from moving phantom measurements and clinical patient measurements showed up to 84.58% decrease in absorption (μa) variance and up to 92.63% decrease in reduced-scattering (μs') variance. Stationary phantom test-measurements showed almost no difference between motion corrected and standard processing. Conclusion: SFDI motion correction is necessary for obtaining high-fidelity in-vivo optical property measurements of pigmented lesions in a clinical setting.

Paper Details

Date Published: 17 February 2011
PDF: 12 pages
Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78830P (17 February 2011); doi: 10.1117/12.876720
Show Author Affiliations
John Quan Nguyen, Beckman Laser Institute and Medical Clinic (United States)
Rolf B. Saager, Beckman Laser Institute and Medical Clinic (United States)
David J. Cuccia, Modulated Imaging, Inc. (United States)
Kristen M. Kelly, Univ. of California, Irvine (United States)
David Hsiang, Univ. of California, Irvine (United States)
Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (United States)

Published in SPIE Proceedings Vol. 7883:
Photonic Therapeutics and Diagnostics VII
Kenton W. Gregory M.D.; Nikiforos Kollias; Andreas Mandelis; Henry Hirschberg M.D.; Hyun Wook Kang; Anita Mahadevan-Jansen; Brian Jet-Fei Wong M.D.; Justus F. R. Ilgner M.D.; Bodo E. Knudsen M.D.; E. Duco Jansen; Steen J. Madsen; Guillermo J. Tearney; Bernard Choi; Haishan Zeng; Laura Marcu, Editor(s)

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