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Proceedings Paper

Storable near-infrared chemiluminescent probes for in vivo optical imaging
Author(s): Bradley D. Smith
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Paper Abstract

A new class of chemiluminescent and fluorescent dyes and dye-doped nanoparticles can be stored at zero degrees and then made to emit near-infrared light by warming to body temperature (no chemical or electrical stimulus is needed). In vivo chemiluminescence imaging permits identification of target sites that are five times deeper than planar fluorescence imaging. A new imaging paradigm employs the dual modality probes first in high contrast chemiluminescence mode to locate relatively deep anatomical locations in vivo and subsequently in fluorescent mode to identify the microscopic targets within thin histopathology sections taken from the same specimen.

Paper Details

Date Published: 11 February 2011
PDF: 6 pages
Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791013 (11 February 2011); doi: 10.1117/12.876709
Show Author Affiliations
Bradley D. Smith, Univ. of Notre Dame (United States)


Published in SPIE Proceedings Vol. 7910:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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