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Proceedings Paper

Near-infrared Au nanorods in photodynamic therapy, hyperthermia agents, and near-infrared optical imaging
Author(s): Wen-Shuo Kuo; Chich-Neng Chang; Yi-Ting Chang; Meng-Heng Yang; Yi-Hsin Chien; Shean-Jen Chen; Chen-Sheng Yeh
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Paper Abstract

The development of multifunctional nanomaterials is currently a topic of interest in the field of nanotechnology. Integrated systems that incorporate therapeutics, molecular targeting, and diagnostic imaging capabilities are considered to be the next generation of multifunctional nanomedicine. In this work, we present the first example of using Au nanorods simultaneously serving not only as photodynamic and photothermal agents to destroy A549 malignant cells but also as optical contrast agents simultaneously to monitor cellular image. Au nanorods were successfully conjugated with hydrophilic photosensitizer, indocyanine green (ICG), to achieve photodynamic therapy (PDT) and hyperthermia. With the combination of PDT and hyperthermia proved to be efficiently killing cancer cells as compared to PDT or hyperthermia treatment alone and enhanced the effectiveness of photodestruction. Moreover, Au nanorods conjugated with ICG displayed high chemical stability and simultaneously acted as a promising cellular image probe. As a result, the preparation of Au nanorods conjugated with photosensitizers as well as their use in biomedical applications is valuable developments in multifunctional nanomaterials.

Paper Details

Date Published: 11 February 2011
PDF: 13 pages
Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791009 (11 February 2011); doi: 10.1117/12.876667
Show Author Affiliations
Wen-Shuo Kuo, National Cheng Kung Univ. (Taiwan)
Chich-Neng Chang, National Cheng Kung Univ. (Taiwan)
Yi-Ting Chang, National Cheng Kung Univ. (Taiwan)
Meng-Heng Yang, National Chung Hsing Univ. (Taiwan)
Yi-Hsin Chien, National Cheng Kung Univ. (Taiwan)
Shean-Jen Chen, National Cheng Kung Univ. (Taiwan)
Univ. of Connecticut Health Ctr. (United States)
Chen-Sheng Yeh, National Cheng Kung Univ. (Taiwan)

Published in SPIE Proceedings Vol. 7910:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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