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Proceedings Paper

Comparison of iron oxide nanoparticle and microwave hyperthermia alone or combined with cisplatinum in murine breast tumors
Author(s): Alicia A. Petryk; Robert V. Stigliano; Andrew J. Giustini; Rachel E. Gottesman; B. Stuart Trembly; Peter A. Kaufman; P. Jack Hoopes
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Paper Abstract

Surgery, radiation and chemotherapy are currently the most commonly used cancer therapies. Hyperthermia has been shown to work effectively with radiation and chemotherapy cancer treatments. The major obstacle faced by previous hyperthermia techniques has been the inability to deliver heat to the tumor in a precise manner. The ability to deliver cytotoxic hyperthermia to tumors (from within individual cells) via iron oxide magnetic nanoparticles (mNP) is a promising new technology that has the ability to greatly improve the therapeutic ratio of hyperthermia as an individual modality and as an adjuvant therapy in combination with other modalities. Although the parameters have yet to be conclusively defined, preliminary data suggests mNP hyperthermia can achieve greater cytotoxicity (in vitro) than conventional water bath hyperthermia methods. At this time, our theory is that intracellular nanoparticle heating is more effective in achieving the combined effect than extracellular heating techniques.1 However, understanding the importance of mNP association and uptake is critical in understanding the potential novelty of the heating modality. Our preliminary data suggests that the mNP heating technique, which did not provide time for particle uptake by the cells, resulted in similar efficacy to microwave hyperthermia. mNP hyperthermia/cisplatinum results have shown a tumor growth delay greater than either modality alone at comparable doses.

Paper Details

Date Published: 23 February 2011
PDF: 7 pages
Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 790119 (23 February 2011); doi: 10.1117/12.876535
Show Author Affiliations
Alicia A. Petryk, Thayer School of Engineering, Dartmouth College (United States)
Robert V. Stigliano, Thayer School of Engineering, Dartmouth College (United States)
Andrew J. Giustini, Thayer School of Engineering, Dartmouth College (United States)
Dartmouth Medical School (United States)
Rachel E. Gottesman, Carleton College (United States)
B. Stuart Trembly, Thayer School of Engineering, Dartmouth College (United States)
Peter A. Kaufman, Dartmouth-Hitchcock Medical Center (United States)
P. Jack Hoopes, Thayer School of Engineering, Dartmouth College (United States)
Dartmouth Medical School (United States)


Published in SPIE Proceedings Vol. 7901:
Energy-based Treatment of Tissue and Assessment VI
Thomas P. Ryan, Editor(s)

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