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Proceedings Paper

Accelerated binding kinetics by surface acoustic waves (SAW) micromixing in surface plasmon resonance (SPR) system for biodetection
Author(s): Alan Renaudin; Vincent Chabot; Etienne Grondin; Vincent Aimez; Paul G. Charette
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Paper Abstract

A design incorporating surface plasmon resonance (SPR) biosensing and surface acoustic wave (SAW) active microfluidic mixing, integrated on a single LiNbO3 piezoelectric substrate, is presented. Validation experiments show that SAW-mixing (microstreaming) results in accelerated binding kinetics (time-to-saturation) for a standard assay with appropriate SAW excitation parameters. Since both SPR sensors and SAW transducers can be fabricated simultaneously using low-cost microfabrication methods, the proposed design should contribute to improved lab-on-chip devices for detecting and identifying biomolecules of interest with greater accuracy and speed across multiple applications.

Paper Details

Date Published: 14 February 2011
PDF: 9 pages
Proc. SPIE 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, 79290M (14 February 2011); doi: 10.1117/12.876508
Show Author Affiliations
Alan Renaudin, Univ. de Sherbrooke (Canada)
Vincent Chabot, Univ. de Sherbrooke (Canada)
Etienne Grondin, Univ. de Sherbrooke (Canada)
Vincent Aimez, Univ. de Sherbrooke (Canada)
Paul G. Charette, Univ. de Sherbrooke (Canada)

Published in SPIE Proceedings Vol. 7929:
Microfluidics, BioMEMS, and Medical Microsystems IX
Holger Becker; Bonnie L. Gray, Editor(s)

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