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Proceedings Paper

High-sensitive nonlinear detection of steroids by resonant double grating waveguide structures-based immunosensors
Author(s): Alejandro Muriano; J.-Pablo Salvador; Roger Galve; M.-Pilar Marco; Anisha Thayil K.N.; Pablo Loza-Alvarez; Silvia Soria
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Paper Abstract

We report the non linear fluorescence real-time detection of methylboldenone, an androgenic anabolic steroid used illegally as growth promoter based on a resonant sensing chip: a double grating waveguide structure. The limit of detection of this synthetic steroid is two orders of magnitude lower than the Minimum Required Performance Limit required by the World Anti-Doping Agency. The immunoreagents have been have been immobilized onto the surface of the resonant sensor after being activated with phosphonohexanoic acid spacers. The developed immunosensor presents great potential as a robust sensing device for fast and early detection of illegal dopants and food contaminants.

Paper Details

Date Published: 17 January 2011
PDF: 7 pages
Proc. SPIE 7941, Integrated Optics: Devices, Materials, and Technologies XV, 794114 (17 January 2011); doi: 10.1117/12.876456
Show Author Affiliations
Alejandro Muriano, Consejo Superior de Investigaciones Científicas (Spain)
CIBER de Bioingeniería, Biomateriales y Nanomedicina (Spain)
J.-Pablo Salvador, CIBER de Bioingeniería, Biomateriales y Nanomedicina (Spain)
Consejo Superior de Investigaciones Científicas (Spain)
Roger Galve, Consejo Superior de Investigaciones Científicas (Spain)
CIBER de Bioingeniería, Biomateriales y Nanomedicina (Spain)
M.-Pilar Marco, Consejo Superior de Investigaciones Científicas (Spain)
CIBER de Bioingeniería, Biomateriales y Nanomedicina (Spain)
Anisha Thayil K.N., Institut de Cièncias Fotònicas (Spain)
Pablo Loza-Alvarez, Institut de Cièncias Fotònicas (Spain)
Silvia Soria, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)


Published in SPIE Proceedings Vol. 7941:
Integrated Optics: Devices, Materials, and Technologies XV
Jean Emmanuel Broquin; Gualtiero Nunzi Conti, Editor(s)

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