Share Email Print
cover

Proceedings Paper

Dual thermal ablation modality of solid tumors in a mouse model
Author(s): Gal Shafirstein; Klressa Barnes; Leah Hennings; Jessica Webber; Eduardo G. Moros; Beata Przybyla; Robert J. Griffin
Format Member Price Non-Member Price
PDF $17.00 $21.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Purpose: Develop a new combination therapy consisting of cryoablation and conductive high-temperature ablation for enhanced thermal ablation of solid tumors. Methods: We have constructed an invasive probe that can be used for consecutive cryoablation and hightemperature ablation (C/HTA), with a single insertion. The C/HTA probe was tested, in Balb/c mice bearing solid 4T1 tumors, in comparison to cryoablation and high temperature ablation, only. Three days after ablation, the diameter of the ablated zone was evaluated with pathological examination. Results: The C/HTA device can be used to induce larger ablation zones, in comparison to high temperature or cryoablation alone, and at lower thermal doses and temperatures than either modality alone. Conclusions: The relatively high thermal conductivity of ice, in comparison to water and native tissue, enables rapid heating of the ice-ball that result in improved conductive high temperature ablation. The new dual thermal modality improves ablation outcomes at lower thermal doses in comparison to a single ablation modality.

Paper Details

Date Published: 23 February 2011
PDF: 8 pages
Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010Z (23 February 2011); doi: 10.1117/12.876427
Show Author Affiliations
Gal Shafirstein, Univ. of Arkansas for Medical Sciences (United States)
Klressa Barnes, Univ. of Arkansas for Medical Sciences (United States)
Leah Hennings, Univ. of Arkansas for Medical Sciences (United States)
Jessica Webber, Univ. of Arkansas for Medical Sciences (United States)
Eduardo G. Moros, Univ. of Arkansas for Medical Sciences (United States)
Beata Przybyla, Univ. of Arkansas for Medical Sciences (United States)
Robert J. Griffin, Univ. of Arkansas for Medical Sciences (United States)


Published in SPIE Proceedings Vol. 7901:
Energy-based Treatment of Tissue and Assessment VI
Thomas P. Ryan, Editor(s)

© SPIE. Terms of Use
Back to Top