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Proceedings Paper

Characterization of burn injuries using terahertz time-domain spectroscopy
Author(s): M. Hassan Arbab; Trevor C. Dickey; Dale P. Winebrenner; Antao Chen; Pierre D. Mourad
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Paper Abstract

The accuracy rates of the clinical assessment techniques used in grading burn injuries remain significantly low for partial thickness burns. In this paper, we present experimental results from terahertz characterization of 2nd and 3rd degree burn wounds induced on a rat model. Reflection measurements were obtained from the surface of both burned and normal skin using pulsed terahertz spectroscopy. Signal processing techniques are described for interpretation of the acquired terahertz waveform and differentiation of burn wounds. Furthermore, the progression of burn injuries is shown by comparison between acute characterization and 72-hours survival studies. While the water content of healthy and desiccated skin has been considered as a source of terahertz signal contrast, it is demonstrated that other biological effects such as formation of post-burn interstitial edema as well as the density of the discrete scattering structures in the skin (such as hair follicles, sweat glands, etc.) play a significant role in the terahertz response of the burn wounds.

Paper Details

Date Published: 21 February 2011
PDF: 7 pages
Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 78900Q (21 February 2011); doi: 10.1117/12.876229
Show Author Affiliations
M. Hassan Arbab, Univ. of Washington (United States)
Trevor C. Dickey, Univ. of Washington (United States)
Dale P. Winebrenner, Univ. of Washington (United States)
Antao Chen, Univ. of Washington (United States)
Pierre D. Mourad, Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 7890:
Advanced Biomedical and Clinical Diagnostic Systems IX
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest, Editor(s)

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