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Proceedings Paper

Performance of line-scanning confocal microscopy in human skin: investigation of potential for clinical translation
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Paper Abstract

Line-scanning, using 8-10 optical components, linear-array detectors and custom-FPGA electronics, may enable smaller, simpler and lower-cost confocal microscopes to accelerate translation to the clinic. The adaptability of commercially available low-cost array detectors for confocal microscopy is being investigated. Measurements of optical sectioning and lateral resolution showed good agreement with theory, and are comparable to that of point-scanning systems. LSFs through full thickness of human epidermis show a two-fold degradation in sectioning performance. Imaging of human epidermis in vivo demonstrates nuclear and cellular detail down to the basal layer with a bench top setup and also a compact clinical prototype. Blood flow in oral mucosa can be imaged using the clinical prototype. However, speckle and background noise degrade contrast and resolution of the image.

Paper Details

Date Published: 21 February 2011
PDF: 9 pages
Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 78900O (21 February 2011); doi: 10.1117/12.876171
Show Author Affiliations
Bjorg Larson, Memorial Sloan-Kettering Cancer Ctr. (United States)
Gary Peterson, Memorial Sloan-Kettering Cancer Ctr. (United States)
Sanjeewa Abeytunge, Memorial Sloan-Kettering Cancer Ctr. (United States)
Milind Rajadhyaksha, Memorial Sloan-Kettering Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 7890:
Advanced Biomedical and Clinical Diagnostic Systems IX
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest, Editor(s)

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