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Proceedings Paper

Synchronous luminescence spectroscopic characterization of blood elements of normal and patients with cervical cancer
Author(s): K. Muthuvelu; Sivabalan Shanmugam; Dornadula Koteeswaran; S. Srinivasan; P. Venkatesan; Prakasarao Aruna; Singaravelu Ganesan
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Paper Abstract

In this study the diagnostic potential of synchronous luminescence spectroscopy (SLS) technique for the characterization of normal and different pathological condition of cervix viz., moderately differentiated squamous cell carcinoma (MDSCC), poorly differentiated squamous cell carcinoma (PDSCC) and well differentiated squamous cell carcinoma (WDSSC). Synchronous fluorescence spectra were measured for 70 abnormal cases and 30 normal subjects. Characteristic, highly resolved peaks and significant spectral differences between normal and MDSCC, PDSCC and WDSCC cervical blood formed elements were obtained. The synchronous luminescence spectra of formed elements of normal and abnormal cervical cancer patients were subjected to statistical analysis. Synchronous luminescence spectroscopy provides 90% sensitivity and 92.6% specificity.

Paper Details

Date Published: 16 February 2011
PDF: 5 pages
Proc. SPIE 7895, Optical Biopsy IX, 78950F (16 February 2011); doi: 10.1117/12.876164
Show Author Affiliations
K. Muthuvelu, Stanley Medical College & Hospital (India)
Sivabalan Shanmugam, Anna Univ. Chennai (India)
Dornadula Koteeswaran, Meenakshi Ammal Dental College & Hopsital (India)
S. Srinivasan, Tuberculosis Research Ctr. (India)
P. Venkatesan, Anna Univ. Chennai (India)
Prakasarao Aruna, Anna Univ. Chennai (India)
Singaravelu Ganesan, Anna Univ. Chennai (India)

Published in SPIE Proceedings Vol. 7895:
Optical Biopsy IX
Robert R. Alfano, Editor(s)

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