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Proceedings Paper

Doppler velocity detection limitations in spectrometer and swept-source Fourier-domain optical coherence tomography
Author(s): Hansford C. Hendargo; Ryan P. McNabb; Al-Hafeez Dhalla; Neal Shepherd; Joseph A. Izatt
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Paper Abstract

Recent advances in Doppler and variance techniques have enabled high sensitivity imaging in regions of biological flow to measure blood velocities and vascular perfusion. In recent years, the sensitivity and imaging speed benefits of Fourier domain OCT have become apparent. Spectrometer-based and wavelength-swept implementations have both undergone rapid development. Comparative analysis of the potential benefits and limitations for the various configurations would be useful for matching technology capabilities to specific clinical problems. Here we take a first step in such a comparative analysis by presenting theoretical predictions and experimental results characterizing the lower and upper observable velocity limits in spectrometer-based versus swept-source Doppler OCT. Furthermore, we characterize the washout limit, the velocity at which signal degradation results in loss of flow information. We present comparative results from phantom flow data as well as retinal data obtained with a commercial spectrometer OCT system and a custom high-speed swept-source retinal OCT system.

Paper Details

Date Published: 15 February 2011
PDF: 8 pages
Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 788911 (15 February 2011); doi: 10.1117/12.876013
Show Author Affiliations
Hansford C. Hendargo, Duke Univ. (United States)
Ryan P. McNabb, Duke Univ. (United States)
Al-Hafeez Dhalla, Duke Univ. (United States)
Neal Shepherd, Duke Univ. (United States)
Joseph A. Izatt, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 7889:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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