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Proceedings Paper

Development and validation of a combined photoacoustic micro-ultrasound system for in vivo oxygen saturation estimation
Author(s): A. Needles; A. Heinmiller; P. Ephrat; D. Bates; C. Bilan-Tracey; C. Theodoropoulos; D. Hirson; F. S. Foster
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Paper Abstract

Photoacoustic (PA) Imaging can estimate the spatial distribution of oxygen saturation (sO2) and total hemoglobin concentration (HbT) in blood, and be co-registered with B-Mode ultrasound images of the surrounding anatomy. This study will focus on the development of a PA imaging mode on a commercially available array based micro-ultrasound (μUS) system that is capable of creating such images. The system will then be validated in vivo against a complementary technique for measuring partial pressure of oxygen in blood (pO2). The pO2 estimates are converted to sO2 values based on a standard dissociation curve found in the literature. Finally, the system will be used for assessing oxygenation in a murine model of ischemia, both during injury and recovery.

Paper Details

Date Published: 19 February 2011
PDF: 8 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78992D (19 February 2011); doi: 10.1117/12.875846
Show Author Affiliations
A. Needles, Visualsonics Inc. (Canada)
A. Heinmiller, Visualsonics Inc. (Canada)
P. Ephrat, Visualsonics Inc. (Canada)
D. Bates, Visualsonics Inc. (Canada)
C. Bilan-Tracey, Visualsonics Inc. (Canada)
C. Theodoropoulos, Visualsonics Inc. (Canada)
D. Hirson, Visualsonics Inc. (Canada)
F. S. Foster, Visualsonics Inc. (Canada)
Sunnybrook Health Sciences Ctr. (Canada)


Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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