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Proceedings Paper

Three-dimensional angular domain optical projection tomography
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Paper Abstract

Angular Domain Imaging (ADI) has been previously demonstrated to generate projection images of attenuating targets embedded within a turbid medium. The imaging system employs a silicon micro-tunnel array positioned between the sample and the detection system to reject scattered photons that have deviated from the initial propagation direction and to select for ballistic and quasi-ballistic photons that have retained their forward trajectory. Two dimensional tomographic images can be reconstructed from ADI projections collected at a multitude of angles. The objective of this work was to extend the system to three dimensions by collecting several tomographic images and stacking the reconstructed slices to generate a three dimensional volume representative of the imaging target. A diode laser (808nm, CW) with a beam expander was used to illuminate the sample cuvette. An Angular Filter Array (AFA) of 80 μm × 80 μm square-shaped tunnels 2 cm in length was used to select for image forming quasi-ballistic photons. Images were detected with a linear CCD. Our approach was to use a SCARA robot to rotate and translate the sample to collect sufficient projections to reconstruct a three dimensional volume. A custom designed 3D target consisting of 4 truncated cones was imaged and reconstructed with filtered backprojection and iterative methods. A 0.5 mm graphite rod was used to collect the forward model, while a truncated pseudoinverse was used to approximate the backward model for the iterative algorithm.

Paper Details

Date Published: 17 February 2011
PDF: 8 pages
Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78970V (17 February 2011); doi: 10.1117/12.875828
Show Author Affiliations
Eldon Ng, Lawson Health Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Fartash Vasefi, Lawson Health Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Simon Fraser Univ. (Canada)
Michael Roumeliotis, Lawson Health Research Institute (Canada)
The Univ. of Western Ontario (Canada)
Bozena Kaminska, Simon Fraser Univ. (Canada)
Jeffrey J. L. Carson, Lawson Health Research Institute (Canada)
The Univ. of Western Ontario (Canada)


Published in SPIE Proceedings Vol. 7897:
Optical Interactions with Tissue and Cells XXII
E. Duco Jansen; Robert J. Thomas, Editor(s)

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