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Proceedings Paper

Continuous-wave and frequency domain optimization in breast tomosynthesis-guided diffuse spectroscopy
Author(s): Kelly E. Michaelsen; Venkataramanan Krishnaswamy; Brian W. Pogue; Keith D. Paulsen
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Paper Abstract

A combined tomosynthesis and diffuse spectroscopy system may provide both spatial and physiological information about breast tissue. Using patient tomosynthesis images and simulated near infrared measurements, it is possible to accurately reconstruct for hemoglobin, water and lipid concentrations. This study utilizes both frequency domain and continuous wave components, given the constraints of a projection geometry but with broadband illumination in order to accurately recover chromophore concentrations from the segmented tissue regions. This analysis will assist in determining the optimum hardware components for a combined system that is currently being built, in order to achieve the best possible accuracy in quantifying tissue properties. Comparing several different configurations including variations in the number of wavelengths, number of regions reconstructed as well as reconstruction methods within the frequency domain components of the system may decrease the complexity, cost and examination time without significant decreases in accuracy.

Paper Details

Date Published: 1 March 2011
PDF: 8 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962K (1 March 2011); doi: 10.1117/12.875817
Show Author Affiliations
Kelly E. Michaelsen, Thayer School of Engineering, Dartmouth College (United States)
Venkataramanan Krishnaswamy, Thayer School of Engineering, Dartmouth College (United States)
Brian W. Pogue, Thayer School of Engineering, Dartmouth College (United States)
Keith D. Paulsen, Thayer School of Engineering, Dartmouth College (United States)


Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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