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Proceedings Paper

Using wide-field quantitative diffuse reflectance spectroscopy in combination with high-resolution imaging for margin assessment
Author(s): Stephanie Kennedy; Jenna Mueller; Torre Bydlon; J. Quincy Brown; Nimmi Ramanujam
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Paper Abstract

Due to the large number of women diagnosed with breast cancer and the lack of intra-operative tools, breast cancer margin assessment presents a significant unmet clinical need. Diffuse reflectance spectral imaging provides a method for quantitatively interrogating margins of lumpectomy specimens. We have previously found that [β- carotene]/μs' is a diagnostically important parameter but both parameters, [β-carotene] and μs', were derived from a low resolution parameter map and are subject to the tissue type and heterogeneity present in the breast. In this study, we used diffuse reflectance measurements from individual sites co-registered with high resolution microendoscopy (HRME) images to determine if the combined performance of these technologies could improve margin assessment. By comparing the optical parameters of [β-carotene] and μs' to the quantitative HRME image endpoints of feature size, feature density and normalized fluorescence, we determined that adding HRME to spectral imaging can improve the specificity of our diffuse reflectance spectral imaging system.

Paper Details

Date Published: 23 February 2011
PDF: 8 pages
Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 78900C (23 February 2011); doi: 10.1117/12.875735
Show Author Affiliations
Stephanie Kennedy, Duke Univ. (United States)
Jenna Mueller, Duke Univ. (United States)
Torre Bydlon, Duke Univ. (United States)
J. Quincy Brown, Duke Univ. (United States)
Nimmi Ramanujam, Duke Univ. (United States)


Published in SPIE Proceedings Vol. 7890:
Advanced Biomedical and Clinical Diagnostic Systems IX
Anita Mahadevan-Jansen; Tuan Vo-Dinh; Warren S. Grundfest, Editor(s)

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