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Proceedings Paper

High sensitive volumetric imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography
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Paper Abstract

We present a non-invasive, label-free imaging technique called Ultrahigh Sensitive Optical Microangiography (UHSOMAG) for high sensitive volumetric imaging of renal microcirculation. The UHS-OMAG imaging system is based on spectral domain optical coherence tomography (SD-OCT), which uses a 47000 A-line scan rate CCD camera to perform an imaging speed of 150 frames per second that takes only ~7 seconds to acquire a 3D image. The technique, capable of measuring slow blood flow down to 4 um/s, is sensitive enough to image capillary networks, such as peritubular capillaries and glomerulus within renal cortex. We show superior performance of UHS-OMAG in providing depthresolved volumetric images of rich renal microcirculation. We monitored the dynamics of renal microvasculature during renal ischemia and reperfusion. Obvious reduction of renal microvascular density due to renal ischemia was visualized and quantitatively analyzed. This technique can be helpful for the assessment of chronic kidney disease (CKD) which relates to abnormal microvasculature.

Paper Details

Date Published: 10 February 2011
PDF: 4 pages
Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 789816 (10 February 2011); doi: 10.1117/12.875694
Show Author Affiliations
Zhongwei Zhi, Univ. of Washington (United States)
Yeongri Jung, Univ. of Washington (United States)
Yali Jia, Univ. of Washington (United States)
Lin An, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 7898:
Dynamics and Fluctuations in Biomedical Photonics VIII
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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