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Proceedings Paper

Methodical study on plaque characterization using integrated vascular ultrasound, strain and spectroscopic photoacoustic imaging
Author(s): Iulia M. Graf; Jimmy Su; Doug Yeager; James Amirian; Richard Smalling; Stanislav Emelianov
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Paper Abstract

Carotid atherosclerosis has been identified as a potential risk factor for cerebrovascular events, but information about its direct effect on the risk of recurrent stroke is limited due to incomplete diagnosis. The combination of vascular ultrasound, strain rate and spectroscopic photoacoustics could improve the timely diagnosis of plaque status and risk of rupturing. Current ultrasound techniques can noninvasively image the anatomy of carotid arteries. The spatio-temporal variation in displacement of different regions within the arterial wall can be derived from ultrasound radio frequency data; therefore an ultrasound based strain rate imaging modality can be used to reveal changes in arterial mechanical properties. Additionally, spectroscopic photoacoustic imaging can provide information on the optical absorption properties of arterial tissue and it can be used to identify the location of specific tissue components, such as lipid pools. An imaging technique combining ultrasound, strain rate and spectroscopic photoacoustics was tested on an excised atherosclerotic rabbit aorta. The ultrasound image illustrates inhomogeneities in arterial wall thickness, the strain rate indicates the arterial segment with reduced elasticity and the spectroscopic photoacoustic image illustrates the accumulation of lipids. The results demonstrated that ultrasound, strain rate and spectroscopic photoacoustic imaging are complementary. Thus the integration of the three imaging modalities advances the characterization of atherosclerotic plaques.

Paper Details

Date Published: 10 February 2011
PDF: 7 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789902 (10 February 2011); doi: 10.1117/12.875689
Show Author Affiliations
Iulia M. Graf, The Univ. of Texas at Austin (United States)
Jimmy Su, The Univ. of Texas at Austin (United States)
Doug Yeager, The Univ. of Texas at Austin (United States)
James Amirian, The Univ. of Texas at Houston (United States)
Richard Smalling, The Univ. of Texas at Houston (United States)
Stanislav Emelianov, The Univ. of Texas at Austin (United States)
The Univ. of Texas at Houston (United States)


Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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