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Proceedings Paper

The impact of aberrations on object reconstruction with interferometric synthetic aperture microscopy
Author(s): Steven G. Adie; Benedikt W. Graf; Adeel Ahmad; Budiman Darbarsyah; Stephen A. Boppart; P. Scott Carney
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Paper Abstract

Interferometric synthetic aperture microscopy (ISAM) reconstructs the scattering potential of a sample with spatially invariant resolution, based on the incident beam profile, the beam scan pattern, the physical model of light sample interaction, and subsequent light collection by the system. In practice, aberrations may influence the beam profile, particularly at higher NA, when ISAM is expected to provide maximum benefit over optical coherence microscopy. Thus it is of interest to determine the effects of aberrations on ISAM reconstructions. In this paper we present the forward model incorporating the effects of aberrations, which forms the basis for aberration correction in ISAM. Simulations and experimental results show that when operating far from focus, modest amounts of spherical aberration can introduce artifacts to the point-spread function, even at relatively low NA ~ 0.1-0.2. Further work will investigate computational methods to correct the effects of aberrations, i.e. to perform virtual adaptive optics.

Paper Details

Date Published: 16 February 2011
PDF: 8 pages
Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 78891O (16 February 2011); doi: 10.1117/12.875592
Show Author Affiliations
Steven G. Adie, Beckman Institute for Advanced Science and Technology (United States)
Benedikt W. Graf, Beckman Institute for Advanced Science and Technology (United States)
Univ. of Illinois at Urbana-Champaign (United States)
Adeel Ahmad, Beckman Institute for Advanced Science and Technology (United States)
Univ. of Illinois at Urbana-Champaign (United States)
Budiman Darbarsyah, Beckman Institute for Advanced Science and Technology (United States)
Univ. of Illinois at Urbana-Champaign (United States)
Stephen A. Boppart, Beckman Institute for Advanced Science and Technology (United States)
Univ. of Illinois at Urbana-Champaign (United States)
P. Scott Carney, Beckman Institute for Advanced Science and Technology (United States)
Univ. of Illinois at Urbana-Champaign (United States)


Published in SPIE Proceedings Vol. 7889:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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