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Proceedings Paper

Optical tomographic imaging of the hemodynamic response to a breath hold in breast cancer patients
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Paper Abstract

Continuous wave optical tomography is non-ionizing, uses endogenous contrast, and can be performed quickly and at low cost which makes it a suitable imaging modality for breast cancer screening. Using multiple wavelengths of light to illuminate the breast at various angles, three-dimensional images of the distribution of chromophores such as oxy- and deoxy-hemoglobin can help identify cancerous tissue. Dynamic optical imaging can provide additional insight into cancer characteristics such as angiogenesis and metabolism. Here we present the first clinical data acquired with our novel digital breast imaging system. This system is based upon a Digital Signal Processor (DSP) architecture that leverages the immediate digitization of acquired analog data to reduce noise and quickly process large amounts of data. Employing this new instrument we have investigated the dynamic changes due to a breath hold and its potential for use in breast cancer screening. Over the course of a breath hold, images have been collected simultaneously from both breasts at a rate of 1.7 frames per second with 32 sources and 64 detectors per breast and four wavelengths of light at 765, 805, 827, and 905nm. Initial results involving one healthy volunteer and one breast cancer patient support the potential use of dynamic imaging for breast cancer detection.

Paper Details

Date Published: 1 March 2011
PDF: 8 pages
Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962J (1 March 2011); doi: 10.1117/12.875461
Show Author Affiliations
Molly L. Flexman, Columbia Univ. (United States)
Michael A. Khalil, Columbia Univ. (United States)
Rabah M. Al Abdi, SUNY Downstate Medical Ctr. (United States)
Beatriu Reig, Columbia Univ. Medical Ctr. (United States)
Christopher J. Fong, Columbia Univ. (United States)
Dawn Hershman, Columbia Univ. Medical Ctr. (United States)
Elise Desperito, Columbia Univ. Medical Ctr. (United States)
Randall L. Barbour, SUNY Downstate Medical Ctr. (United States)
Andreas H. Hielscher, Columbia Univ. (United States)
Columbia Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 7896:
Optical Tomography and Spectroscopy of Tissue IX
Bruce Jason Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva Marie Sevick-Muraca; Robert R. Alfano, Editor(s)

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