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Proceedings Paper

Determining how uncertainties in optical properties affect light dose calculations for PDT
Author(s): Julia Sandell; Jarod C. Finlay; Timothy C. Zhu
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Paper Abstract

The effectiveness of photodynamic treatment depends on several factors including an accurate knowledge of optical properties of the tissue to be treated. In order to correctly determine the needed light dose, the values of tissue optical properties must be well known. In this study we consider how the uncertainties in the measured values of optical properties affect the uncertainty in light dosimetry. By using phantoms with known optical properties we determine the uncertainties for several algorithms currently in the literature. We calculate the light fluence uncertainties using a finite element model solution to the diffusion equation in a cavity geometry. Using these uncertainties we conduct a statistical analysis, building a three dimensional space of uncertainties in μa, μs', and light dose. By characterizing this space we gain an understanding of the trend in uncertainties and determine which algorithms provide the most accurate light dose.

Paper Details

Date Published: 11 February 2011
PDF: 6 pages
Proc. SPIE 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, 78860N (11 February 2011); doi: 10.1117/12.875378
Show Author Affiliations
Julia Sandell, Univ. of Pennsylvania (United States)
Jarod C. Finlay, Univ. of Pennsylvania (United States)
Timothy C. Zhu, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 7886:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX
David H. Kessel; Tayyaba Hasan, Editor(s)

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