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Proceedings Paper

Aptamer-based localized surface plasmon resonance sensor for monitoring glycated proteins
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Paper Abstract

The peak extinction wavelength of the nano-size noble metal localized surface plasmon resonance (LSPR) spectrum is unexpectedly sensitive to nanoparticle size, shape, and local external dielectric environment. This sensitivity to the environment has enabled the development of a new class of nanoscale affinity biosensors. Aptamer (single strand DNA) based gold nanorods (Au NRs) and magnetic beads (MBs) combined LSPR biosensor has been developed for the rapid and label-free detection of glycated proteins in small solution volumes. An aptamer self-assembly monolayer (SAM) functionalized surface plasmon resonance sensor has also been developed for comparison purposes. For demoonstration purposes, albumin and thrombin are used initially as the target proteins. The ability to monitor such molecules in the body could facilitate the diagnosis and treatment of diabetic patients.

Paper Details

Date Published: 12 February 2011
PDF: 5 pages
Proc. SPIE 7911, Plasmonics in Biology and Medicine VIII, 79110E (12 February 2011); doi: 10.1117/12.875284
Show Author Affiliations
Rui Zheng, The Univ. of Toledo (United States)
Brent D. Cameron, The Univ. of Toledo (United States)


Published in SPIE Proceedings Vol. 7911:
Plasmonics in Biology and Medicine VIII
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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