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Proceedings Paper

Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques
Author(s): Daniel Razansky; Niels J. Harlaar; Jan-Luuk Hillebrands; Adrian Taruttis; Eva Herzog; Clark Zeebregts; Goitzen van Dam; Vasilis Ntziachristos
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Paper Abstract

In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.

Paper Details

Date Published: 10 February 2011
PDF: 6 pages
Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789905 (10 February 2011); doi: 10.1117/12.875271
Show Author Affiliations
Daniel Razansky, Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)
Niels J. Harlaar, Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)
Jan-Luuk Hillebrands, Univ. Medical Ctr. Groningen (Netherlands)
Adrian Taruttis, Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)
Eva Herzog, Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)
Clark Zeebregts, Univ. Medical Ctr. Groningen (Netherlands)
Goitzen van Dam, Univ. Medical Ctr. Groningen (Netherlands)
Vasilis Ntziachristos, Technical Univ. of Munich and Helmholtz Ctr. Munich (Germany)


Published in SPIE Proceedings Vol. 7899:
Photons Plus Ultrasound: Imaging and Sensing 2011
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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