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Proceedings Paper

Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage
Author(s): Niculae Mincu; Dao Chao Huang; Marilyse Piche; Guobin Ma
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Paper Abstract

The continuously expanding number of fluorescent probes developed for molecular imaging in vivo requires new instruments, more flexible and with higher quantification power. Responding to those requirements we propose a new instrument: it combines the sensitivity of time correlated single photon detection with the extended spectral coverage of a pulsed supercontinuum laser in a sensitive and flexible time-domain platform for in vivo molecular imaging in small animals. The performance of the system is demonstrated on a case study, using NEO-STEM-PMSR50- PEG fluorescent silica nanoprobes and sequential imaging of CD-1 nude mice.

Paper Details

Date Published: 11 February 2011
PDF: 8 pages
Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101K (11 February 2011); doi: 10.1117/12.875214
Show Author Affiliations
Niculae Mincu, Advanced Research Technologies Inc. (Canada)
Dao Chao Huang, Advanced Research Technologies Inc. (Canada)
Marilyse Piche, Advanced Research Technologies Inc. (Canada)
Guobin Ma, Advanced Research Technologies Inc. (Canada)


Published in SPIE Proceedings Vol. 7910:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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