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Proceedings Paper

Detection of familial adenomatous polyposis with polarized spectroscopic imaging and oral vascular density
Author(s): Ali Basiri; Daniel L. Edelstein; Francis M. Giardiello; J. C. Ramella-Roman
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Paper Abstract

Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer in later years. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. Genetic testing is expensive and in some cases deleterious mutations are not found in all patients with a clinical diagnosis of FAP. As such, the early identification of affected individuals could substantially eliminate associated morbidity and mortality. We investigated a novel spectro-polarimetric imaging system to capture images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Total diffused oral mucosal reflectance (OMR) and oral mucosal vascular density (OMVD) were calculated from spectral data collected from 33 patients with gene positive FAP, 5 patients who tested negative for FAP, and 45 controls. A statistically significant difference in OMVD (p < 0.001) was observed between individuals with FAP and controls. Analysis of OMR showed no significant difference between the two subject groups.

Paper Details

Date Published: 17 February 2011
PDF: 7 pages
Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78970P (17 February 2011); doi: 10.1117/12.875193
Show Author Affiliations
Ali Basiri, The Catholic Univ. of America (United States)
Daniel L. Edelstein, The Johns Hopkins Univ. (United States)
Francis M. Giardiello, The Johns Hopkins Univ. (United States)
J. C. Ramella-Roman, The Catholic Univ. of America (United States)
The Johns Hopkins Univ. (United States)

Published in SPIE Proceedings Vol. 7897:
Optical Interactions with Tissue and Cells XXII
E. Duco Jansen; Robert J. Thomas, Editor(s)

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